Advanced LC-MS analysis of Small Molecules

What will you learn?

Note: Since the course will be taught in English, the rest of the description will be in English.

If you routinely work with LC-MS, but feel the need to get more in-dept knowledge and get more out of your results, this is the course for you! During the course Advanced LC-MS analysis for small molecules, you will learn more about the different components of an LC-MS machine, and how to utilize them for quantitative and qualitative analysis of small molecule drugs. The interactive nature of the course will make sure you will gain both theoretical and practical experience and be ready to set up and validate your own experiments.

Content

During the course Advanced LC-MS analysis of small molecules, you will gain the tools you need to set up and validate your own LC-MS assays. You will get more theoretical background of the technique, and gain hands-on experience with sample preparation, quantitative and qualitative analysis, predicting results and assessing their value. You will also learn more about the rules about quality control of analytic methods.

Goal

With the knowledge gained in this course, you can improve your own LC-MS experiments and results. Furthermore, you will be a valuable source of advice for your organization. You will for instance be able to assess project proposals on their bio-analytical methods, advise on the best assays for given components and give advice on other possible methods or follow-up research.

Programme

The course consists of an online component and an in-person component. Before the in-person sessions, participants will work through several webinars covering the general theory. They can also complete short quizzes to reinforce their understanding of the material.

During the course days, the theory will be briefly summarised, followed by an opportunity to ask questions. In addition, various case studies will be discussed to apply the theory in practice.

• Day 1: LC-MS, matrices, bio-analysis, HILIC
• Day 2: Quantification, sample preparation, influence of mobile phase en pH/pKa
• Day 3: Mass spectrometry, derivatisation, internal standard, regulation
• Day 4: Casus

Who can join?

The course LC-MS assays for small molecule drugs is aimed at laboratory workers, analysts, project leaders or other people in the pharmaceutical, biomedical or clinical chemistry field that work with LC-MS but want to expand their knowledge and learn more about sample preparation and setting up quantitative and qualitative assays for small molecule drugs.

What do you need?

• Bachelor or master degree in the life sciences, or AD (NLQF5) or mbo (NLQF4) qualification in the life sciences with at least 5 years of relevant work experience.

Voor organisaties

Wil je medewerkers ontwikkelen, inspelen op veranderingen of werken aan groei? De Hanze biedt maatwerk- en incompanytrajecten die aansluiten op de praktijk en doelen van jouw organisatie. Van losse modules en trainingen tot complete programma’s, flexibel en vaak op locatie. Zo investeer je in de ontwikkeling en toekomst van je medewerkers en organisatie.

Lees meer over maatwerkopleidingen

Practical information

Duration

The course is 8 days, with about 4 online preparation days (on your own speed) and 4 in-person days. The 4 in-person course days are spread over 2 months, and you will be expected from 9:00 till 16:00h.

Study load

The study load for this course is about 140 hours. You will spend 4 days at the Hanze, and there will be about 4 days of webinars (self-paced).

Certificate

You will receive a proof of participation.

Costs

3750 euro (including access to the online environment with study materials, lunch and parking)